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Search Results for " smoothened agonist "

8

Compounds

Cat No. Product Name Synonyms Targets
T1779 SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist Hedgehog/Smoothened , Smo
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.
T4211 SAG hydrochloride (912545-86-9(free base)) Smoothened Agonist HCl Hedgehog/Smoothened
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
T40465 SAG dihydrochloride Hedgehog/Smoothened
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo.
T2450 SANT-1 SANT 1 Hedgehog/Smoothened , Smo
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T22814 GSA-10 Hedgehog/Smoothened
Smoothened (Smo) receptor agonist
T24754 Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5 Hedgehog/Smoothened
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...
T25918 Palmitoyl-L-aspartic acid L-N-Palmitoylaspartic acid
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec...
T35562 Nat-20(S)-yne
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which bin...
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